New research from Marshall University finds a link between the use of walnuts and survival in breast cancer due to the fact that it can suppress the growth of cancer cells.
W. Elaine Hardman, the study author, Ph.D., a lecturer in the Department of Biomedical Sciences at the Marshall University Joan C. Edwards School of Medicine, a Marshall University group uncovered that usage of two ounces of walnuts daily continuously for fourteen days fundamentally changed gene expression in affirmed breast cancers.
This pilot, a two-arm preliminary trial is the most recent of a series of related examinations at Marshall University identified with dietary walnut associated with tumor development, survival and metastasis in breast cancer. The research was published on March 10 paper in the journal Nutrition Research.
“Consumption of walnuts has slowed breast cancer growth and/or reduced the risk of mammary cancer in mice,” Hardman said. “Building on this research, our team hypothesized that walnut consumption would alter gene expression in pathologically-confirmed breast cancers of women in a direction that would decrease breast cancer growth and survival.”
In this first trial, women with large breast lumps were selected and for research and pathology biopsies. Some were given a free hand on the consumption of walnuts while some were selected for the control group.
Promptly following biopsy collection, ladies in the walnut group started to use two ounces of walnuts every day till the end.
Pathological studies affirmed that lumps were breast cancer in all ladies who stayed in the preliminary. At medical procedure, around about fourteen days after the biopsy, extra samples were taken from the breast cancers.
The changes in gene expression in the sample was contrasted with the baseline in every single woman in walnut-consuming (n = 5) and control (n = 5) groups. RNA sequencing expression profiling uncovered that expression of 456 distinguished genes was essentially changed in the tumor because of walnut consumption.
Ingenuity Pathway Analysis demonstrated initiation of pathways that advance apoptosis and cell adhesion and hindrance of pathways that advance cell multiplication and movement.
“These results support the hypothesis that, in humans, walnut consumption could suppress growth and survival of breast cancers,” Hardman said.
“Additional research through a larger-scale study would be needed to clinically confirm that walnut consumption actually does reduce the risk of breast cancer or breast cancer recurrence.”
This research highlights the importance of teaming in modern research. Breast specialists Mary Legenza, an M.D., of Marshall University Joan C. Edwards School of Medicine and Edwards Comprehensive Cancer Center, and James Morgan, M.D., in the past of St. Mary’s Medical Center, gathered biopsies from patient volunteers for the clinical preliminary.
Donald A. Primerano, Ph.D., Jun Fan, Ph.D., and James Denvir, Ph.D., of the Genomics and Bioinformatics Core Facility at Marshall University Joan C. Edwards School of Medicine played out the RNA expression profiling, bioinformatics, and statistical examinations.