Study Points to a Possible Injectable Hormone Therapy to Counter Obesity

It is discovered that in a period of 4 weeks an injection reduces Body weight and glucose levels when injected in obese patients and Diabetics.

A small study was conducted which concluded that the patients lost on Average 4.4 kg and considerable improvements in their blood glucose level.

A weight loss surgery procedure named“Gastric bypass surgery”, is one of the most common types of weight loss surgery. It is known for its effectiveness in reducing excess weight and improving blood sugar levels in patients of diabetes mellitus. However, it may cause complications if the patients disobey the surgery procedure and directions, thus suffering from Abdominal pain, Vomiting, chronic nausea, devitalizing low blood glucose levels.

In a recent research, Imperial College London revealed that one of the reasons for the effectiveness of Gastric bypass surgery is due to the elevated release of three specific hormone combination called ‘GOP’ that normally originate from the bowels. GOP reduces appetite, loss of weight and improves the body’s ability to utilize glucose, previously stored from food.

The objective of the researchers was to discover if the patients are injected with the GOP hormones Glucagon-like Peptide-1, oxyntomodulin and peptide, mimics the high level the same as after surgery, as well as aids in weight loss and declines blood sugar levels.

In the research, GOP treatment was injected by transdermal route into fifteen patients for four weeks with the help of a pump that slowly injects the solution under the skin for every 12 hours a day, beginning one hour before breakfast and disengaging after their last meal of the day. Nutritionist advice on healthy living and weight loss were also given to the patients.

The foremost author of the study, Ms. Tricia Tan, who by profession is a Professor of Metabolic Medicine & Endocrinology at Imperial College Londonsaid, “Obesity and type 2 diabetes can lead to very serious and potentially life-threatening conditions such as cancer, stroke and heart disease.

There is a real need to find new medicines so we can improve and save the lives of many patients. Although this is a small study our new combination hormone treatment is promising and has shown significant improvements in patients’ health in only four weeks. Compared to other methods the treatment is non-invasive and reduced glucose levels to near-normal levels in our patients.”

The research conducted by Imperial College London in alliance with the University of Copenhagen and University College Dublin was presented to The American Diabetes Association 79th Scientific Session Meeting at San Francisco, and it got published in “Diabetes Care”.

The patients were injected with GOP treatment and different trials were conducted at the National Institute for Health Research Imperial Clinical Research Facility at Hammersmith Hospital, part of Imperial College Healthcare NHS Trust.

In Hammersmith Hospital, in a period from 2016 to 2018 the research was done on twenty-six obese patients who were also diagnosed with prediabetes and patients with diabetes. On a Random scale, fifteen patients were injected with GOP treatment and eleven patients were infused with saline solution as a placebo every four weeks.

The conclusions drawn from the experiment were that the patients injected with GOP treatment lost on average 4.4kg, patients infused with saline solution lost 2.5 kg and above all no side effects encountered by this treatment.

In another trial the researchers enrolled twenty-one patients endured with bariatric surgery, to compare their results of GOP treatment against twenty-two patients who took a very low-calorie diet. The glucose monitoring device was constant among all the patients to examine their glucose levels following the GOP hormones injection.

Conclusively, valetudinarians who had undergone bariatric surgery lost 10.3kg and those who took a very low-calorie diet lost 8.3kg. Thus, these patients lost notably more weight than GOP patients.

Regarding this Professor Tan expressed her view: “Although the weight loss was smaller, using the GOP infusion would be preferable as it has fewer side effects than bariatric surgery. This result shows that it is possible to obtain some of the benefits of a gastric bypass operation without undergoing the surgery itself. If further trials are successful, in future we could potentially give this type of treatment to many more patients.”

The team has also deduced numerous effects of GOP; it enables blood glucose levels lowering to near-normal levels, and may also lead to some variation in the blood glucose concentration. An overall improvement in blood glucose levels is observed in patients who had encountered bariatric surgery, but with a greater degree of variations, thus endangered to achieving low blood glucose levels.

The researchers are looking forward to conducting a larger clinical trial to examine the impact of GOP on a greater number of participants for a longer time duration.

This remarkable testing was carried out by Imperial College Academic Health Science Centre, in collaboration with Imperial College London and three NHS hospital trusts. It’s a platform that pursues to benefit people around the globe manipulating scientific discoveries into medical proceedings, ultimately transfiguring human healthcare in a shorter duration of time.

Adeena Tariq

Adeena's professional life has been mostly in hospital management, while studying international business in college. Of course, she now covers topics for us in health.

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