The researchers from the University of Manchester explained that good and sufficient hours of sleep really makes a person fresh and enables him to face the fatigues and severities of the coming day. This study was conducted on mice and is published in “Nature Cell Biology”.
The study results explain the human body’s biological clock, commonly referred to as the “body clock“. It maintains the timing of all body functions such as sleeping cycle, eating habits, etc. The research team investigated the body clock mechanism involved in improving and maintaining the timing of the body when it is active.
With increasing age, the accuracy of the body clock becomes less. With this discovery, we may be able to find out the mysteries related to aging that are still unknown.
The discovery mainly focusses on the extracellular matrix of the body’s cell. The function of the extracellular matrix is to provide the shape biochemical and structural support to the cells. this support is usually in the form of connective tissue including skin, bones, cartilage, and tendons.
More than half of the bodyweight is comprising of the matrix and the other half consists of collagen. According to scientists, this matrix is fully developed in a person when he touches the age of 17.
Researchers found that matrix fibrils are of two types. Fibrils are rope-like collagen structures. Cells interlace these fibrils to form tissues.
One type of fibrils is thick, usually has a diameter of 200 nanometer, which is a million times smaller as compared to a pinhead. Once these fibrils are formed in the body up to the age of 17, they become permanent and unchanged in our bodies.
Thinner fibrils are the second type of fibrils having a diameter of 50 nanometers. These fibrils are sacrificial and fragile. They undergo breakage when the body is dealing with rigors of the whole day. Replenishment of thinner fibrils occurs when the body is at rest during the night.
Mass spectrometry was used to observe the collagen and by using the state of art volumetric electron microscope mouse fibrils were analyzed. The observation was done every four’s hours for two days. The incorporation of thick and thin fibrils occurs randomly when the genes of the body clock knocked out in mice.
According to Professor Kadler, collagen is the most abundant protein in the body and is important in maintaining the structure of the body. it ensures the elasticity, integrity, and strength of connective tissue of the body.
Most of the time our intuitive thinking is that extracellular matrix should worn out and get damaged. But it is not true because an element is made by our body clock that is sacrificial in nature. So, due to this the replenishment of the matrix could be done which ultimately protects the permanent parts of the matrix.
He further explains it with the help of an example that if we build a wall then the bricks are the permanent parts of the wall and paint on it is sacrificial which could be replenished whenever you want to do it. This discovery led scientists to know more about the unlock mysteries about the aging and process of wound healing.